TITLE: POTENTIAL OF A NEW QUATERNARY AMMONIUM SILANE - K21 FOR THE NEXT GENERATION OF BIOMATERIALS
COURSE FEE: Complimentary
CREDITS: This continuing education activity is designated for 1.5 credits
AGD PACE SUBJECT CODE: 010, Basic Sciences, Cariology
CE SUPPORTER: FiteBac Dental LLC
MODE: Electronically Mediated | Live Interactive Webinar
SPEAKERS: Dr. Umer Daood, PhD (See Bio)
TECHNOLOGY REQUIRED: Mobile device, laptop or desktop with internet connection | Google Chrome Browser
INSTRUCTIONS: Upon registration, you will receive a confirmation email from email@example.com. We recommend logging in 15 minutes prior to start time. A course handout will be distributed during the course. At the conclusion of the webinar, attendees will receive an email to complete a quiz/course evaluation for CE Credits.
COURSE SUMMARY: The Quaternary Ammonium Compounds, SiQAC, have been coupled with trialkoxysilanes with methacryloxy or epoxy functionalities via sol-gel platform chemistry that utilises tetraethoxysilane (TEOS) or dimethyldiethoxysilane as the anchoring unit, generating a host of quaternary ammonium silanes (QAS) molecules with antimicrobial activities. Antimicrobial and reparative efficacy of K21 disinfectant is a proof of concept for enhanced killing of bacteria across root dentin acquiring functional type M2 polarization for ethnopharmacological effects. The drug formulation can have great potential for targeting even cancerous cells. K21 can also inhibit the catalytic action of MMPs and SrtA enzymes preventing dentinal and periodontal disease initiation.
Describe K21's specific pocket binding on various MMPs and its production of a classical clouting effect
Demonstrate the expression of M2 polarized subsets and how they show K21 in resolving inflammation and potentiate tissue repair
Discuss how the K21 based drug delivery system leads to reduced migration and adhesion of oral squamous cell carcinoma cells
Describe how in a complex root canal system, the potential to exploit K21 for a feasible therapeutic approach against biofilm infection offering a sufficiently large therapeutic window
Dr. Umer Daood, PhD
Associate Prof. Dr Daood graduated from Baqai Dental College (BDS) Pakistan in 1999 subsequently embarking on a lineup of advanced post graduate qualifications. Dr. Umer Daood holds a Master of Science (MSc) in Oral Sciences and Biomaterials from the National University of Singapore as well as an MSc in Dental Materials from Queen Mary University of London. He obtained his PhD from Prince Philip Dental Hospital at the University of Hong Kong. He is currently enrolled in MSc Molecular Medicine at International Medical University. He is a Member of the Faculty of Dental Surgery of the Royal College Surgeons (MFDS, RCS Glasgow) and holds a Certificate in Periodontology from Queen Elizabeth Hospital, Woolich, London. Dr. Daood has special interests in: Dental Biomaterials, Disinfection in Endodontics, Tissue Engineering of Dentin Structure and Developing New Adhesives and Esthetic restoration. He is currently working as Associate Professor, Head of Restorative Division, School of Dentistry, International Medical University, Kuala Lumpur, Adjunct Faculty Asst. Professor Prince Philip Dental Hospital, HKU at The University of Hong Kong. Dr Daood has more than 85 international high impact publications, book chapters and patents to his name. “I have always loved Science, Biology, History and have a deep interest in Cosmology. Surprisingly, working on research, academics, and diversity, it pulled a great way to combine these interests into a truly rewarding career. Have a great appreciation towards the complexity of life, picked up a career in dentistry, and then into academics and research. Through my experiences, and research, I learnt that researching in dentistry allows one to address real life clinical problems using the information that has evolved since so many years.”
DISCLOSURE OF SPEAKER AND FACULTY COMMERCIAL RELATIONSHIPS: According to Dental CE Academy's Conflict of Interest and Disclosure Policy, faculty and speakers for any course are expected to disclose any economic support, personal interests, or potential bias that may be perceived as creating a conflict related to the material being presented. Disclosure statements are printed in each course description and announced by moderators or individual speakers at the beginning of each presentation. This policy is intended to alert the audience to any potential bias or conflict so that participants may form their own judgments about the material being presented.
CONFLICT OF INTEREST AND FINANCIAL DISCLOSURE OF SPEAKER: The work being presented was funded by FiteBac Dental LLC. This webinar is supported by FiteBac Dental LLC.
DENTAL CE ACADEMY DISCLAIMER: The views expressed and opinions and materials presented during these live and recorded presentations represent the personal views and opinions of the individual speaker and do not necessarily represent the views and opinions of Dental CE Academy or its parent company, Virtual Dontics®. Dental CE Academy assumes no responsibility for the content of the presentations made by the individual speakers. Any suggested protocols for treatment, materials, or services may be based upon the speaker's own clinical experience and should not be construed as Dental CE Academy recommended or endorsed. Selected presentations may include exploratory research or experimental procedures and are intended for informational purposes that may lead to interest and scientific breakthroughs in the fields of dentistry. Dental CE Academy appreciates its educators who share their knowledge and expertise. This level of dedication to dentistry allows our profession to expand and thrive and provokes necessary discussion and understanding.